Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7570486 | 0.83 | P2RX7 (0.64) | NPC1KMT2AHPGDALDH1A1MEN1 | |
| SCHEMBL7514220 | 0.78 | P2RX7 (0.68) | HPGDALDH1A1POLBGAAP2RX7 | |
| SCHEMBL7864022 | 0.71 | P2RX7 (0.46) | KMT2AALDH1A1MEN1KDM4EP2RX7 | |
| SCHEMBL7522787 | 0.70 | P2RX7 (0.58) | P2RX7 | |
| SCHEMBL7517506 | 0.69 | P2RX7 (0.57) | P2RX7 | |
| SCHEMBL8080956 | 0.69 | P2RX7 (0.54) | P2RX7 | |
| SCHEMBL8437113 | 0.69 | KDM4E (0.71) | NPC1KMT2AHPGDALDH1A1POLB | |
| SCHEMBL14708779 | 0.68 | NPC1 (0.53) | NPC1KMT2AHPGDKDM4EGAA | |
| SCHEMBL8084055 | 0.68 | HSD17B10 (0.56) | KMT2AHPGDALDH1A1P2RX7TSHR | |
| SCHEMBL6497265 | 0.68 | P2RX7 (0.56) | HPGDP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036059-A1 | ADAMANTANE DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029661-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |