Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7870341 | 0.91 | CA2 (0.43) | EGFRP4HTMBCL2L1MCL1CA2 | |
| SCHEMBL7871727 | 0.90 | CA2 (0.44) | EGFRP4HTMEPHX2GABRA5CA2 | |
| SCHEMBL7869451 | 0.89 | CA2 (0.49) | EGFRP4HTMCA2 | |
| SCHEMBL7871629 | 0.89 | CA2 (0.46) | EGFRP4HTMEPHX2CA2 | |
| SCHEMBL7869130 | 0.88 | KMT2A (0.44) | EGFRP4HTMCA2 | |
| SCHEMBL7862735 | 0.87 | P4HTM (0.56) | EGFRP4HTMBCL2L1MCL1PTGS2 | |
| SCHEMBL7870554 | 0.86 | NPC1 (0.49) | P4HTMBCL2L1MCL1CA12CA9 | |
| SCHEMBL7867814 | 0.85 | MEN1 (0.48) | P4HTMBCL2L1MCL1CA12CA9 | |
| SCHEMBL7867675 | 0.85 | NPC1 (0.49) | P4HTMBCL2L1MCL1CA2 | |
| SCHEMBL7871673 | 0.85 | ACACB (0.43) | EGFRP4HTMCA12CA9CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |