Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869451 | 0.96 | CA2 (0.49) | CA2EGFRALDH1A1KMT2AKDM4E | |
| SCHEMBL7869130 | 0.91 | KMT2A (0.44) | CA2EGFRALDH1A1LMNAKMT2A | |
| SCHEMBL7862795 | 0.91 | EGFR (0.44) | CA2EGFRP4HTMBCL2L1MCL1 | |
| SCHEMBL7867899 | 0.91 | SMN1; SMN2 (0.43) | CA2LMNAKMT2AP4HTMRAB9A | |
| SCHEMBL7871727 | 0.90 | CA2 (0.44) | CA2EGFRALDH1A1KMT2AP4HTM | |
| SCHEMBL7871629 | 0.89 | CA2 (0.46) | CA2EGFRALDH1A1KMT2AKDM4E | |
| SCHEMBL7869436 | 0.89 | NPC1 (0.44) | P4HTMNPC1RAB9ABCL2L1MCL1 | |
| SCHEMBL7871605 | 0.88 | HSP90AA1 (0.44) | KMT2AP4HTMNPC1RAB9AMEN1 | |
| SCHEMBL7870554 | 0.86 | NPC1 (0.49) | CA2KMT2AP4HTMNPC1RAB9A | |
| SCHEMBL7870566 | 0.86 | EGFR (0.43) | CA2EGFRCYP2C9ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |