Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869443 | 0.91 | P4HTM (0.43) | GABRA5RAB9ANPC1SMN1; SMN2P4HTM | |
| SCHEMBL7862789 | 0.90 | GABRA5 (0.45) | GABRA5RAB9ANPC1SMN1; SMN2CYP2C9 | |
| SCHEMBL7874596 | 0.89 | P4HTM (0.45) | GABRA5RAB9ANPC1SMN1; SMN2P4HTM | |
| SCHEMBL7862679 | 0.88 | P4HTM (0.56) | GABRA5RAB9ANPC1SMN1; SMN2P4HTM | |
| SCHEMBL7871596 | 0.87 | GABRA5 (0.45) | GABRA5RAB9ANPC1SMN1; SMN2P4HTM | |
| SCHEMBL9018289 | 0.87 | P4HTM (0.46) | GABRA5RAB9ANPC1SMN1; SMN2P4HTM | |
| SCHEMBL7869446 | 0.87 | GABRA5 (0.45) | GABRA5RAB9ANPC1SMN1; SMN2P4HTM | |
| SCHEMBL9574736 | 0.85 | GABRA5 (0.50) | GABRA5KMT2AMEN1 | |
| SCHEMBL8868663 | 0.85 | P4HTM (0.52) | RAB9ANPC1SMN1; SMN2P4HTMHPGD | |
| SCHEMBL7871609 | 0.84 | P4HTM (0.55) | GABRA5P4HTMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |