Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874627 | 0.91 | GABRA5 (0.43) | GABRA5RAB9AALDH1A1CXCR1CXCR2 | |
| SCHEMBL7862809 | 0.90 | GABRA5 (0.43) | GABRA5RAB9APOLBCYP2C9CYP2C19 | |
| SCHEMBL7871626 | 0.90 | GABRA5 (0.46) | GABRA5CXCR1CXCR2EPHX2CYP2C9 | |
| SCHEMBL9018098 | 0.87 | CXCR1 (0.44) | GABRA5RAB9AALDH1A1CXCR1CXCR2 | |
| SCHEMBL8869212 | 0.85 | RAB9A (0.48) | GABRA5RAB9AALDH1A1POLBCYP2C9 | |
| SCHEMBL7871752 | 0.84 | CXCR1 (0.39) | GABRA5RAB9AALDH1A1CXCR1CXCR2 | |
| SCHEMBL7862742 | 0.84 | KMT2A (0.51) | RAB9AALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL9574736 | 0.83 | GABRA5 (0.50) | GABRA5ALDH1A1MEN1KMT2A | |
| SCHEMBL9018431 | 0.83 | CXCR2 (0.47) | GABRA5RAB9AALDH1A1CXCR1CXCR2 | |
| SCHEMBL9018316 | 0.82 | CXCR1 (0.45) | GABRA5RAB9AALDH1A1CXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |