Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862809 | 0.91 | GABRA5 (0.43) | P4HTMGABRA5MEN1KMT2ANPC1 | |
| SCHEMBL7874627 | 0.90 | GABRA5 (0.43) | GABRA5RAB9ASMN1; SMN2CXCR1CXCR2 | |
| SCHEMBL7871645 | 0.87 | P4HTM (0.58) | P4HTMGABRA5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7867806 | 0.86 | P4HTM (0.45) | P4HTMGABRA5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8868213 | 0.85 | P4HTM (0.54) | P4HTMMEN1KMT2ANPC1RAB9A | |
| SCHEMBL7867903 | 0.85 | P4HTM (0.44) | P4HTMGABRA5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7862825 | 0.84 | P4HTM (0.43) | P4HTMGABRA5MEN1KMT2ACXCR1 | |
| SCHEMBL7867895 | 0.84 | NPC1 (0.51) | P4HTMGABRA5MEN1KMT2ANPC1 | |
| SCHEMBL9018289 | 0.83 | P4HTM (0.46) | P4HTMGABRA5MEN1KMT2ANPC1 | |
| SCHEMBL9574661 | 0.82 | GABRA5 (0.51) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |