Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.34 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL632416 | 0.84 | LTA4H (0.47) | GRM2LTA4HCNR2PIK3CAALDH1A1 | |
| SCHEMBL632417 | 0.84 | LTA4H (0.47) | GRM2LTA4HCNR2PIK3CAALDH1A1 | |
| SCHEMBL633549 | 0.84 | LTA4H (0.47) | GRM2LTA4HCNR2PIK3CAALDH1A1 | |
| SCHEMBL7864913 | 0.81 | GRM2 (0.39) | GRM2ALDH1A1ADORA3ADORA2AADORA2B | |
| SCHEMBL8805178 | 0.80 | LTA4H (0.56) | GRM2LTA4HCNR2PIK3CAALDH1A1 | |
| SCHEMBL13638809 | 0.77 | KDM4E (0.52) | GRM2LTA4HPIK3CAALDH1A1FGFR1 | |
| SCHEMBL12214 | 0.76 | LTA4H (0.57) | GRM2LTA4HCNR2ALDH1A1PDE1B | |
| SCHEMBL14960477 | 0.76 | LTA4H (0.57) | GRM2LTA4HCNR2ALDH1A1PDE1B | |
| SCHEMBL18491483 | 0.76 | HRH3 (0.54) | PIK3CAALDH1A1MAPTSMN1; SMN2HRH3 | |
| SCHEMBL30508309 | 0.75 | LTA4H (0.56) | GRM2LTA4HCNR2PIK3CAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120237-A1 | IMIDAZOLE SUBSTITUTED PYRIMIDINES USEFUL IN THE TREATMENT OF GLYCOGEN SYNTHASE KINASE 3 RELATED DISORDERS SUCH AS ALZHEIMER'S DISEASE | ASTRAZENECA AB (SE) | 2010-10-21 | — | — | WO | disclosed |