SCHEMBL7863503

SCHEMBL7863503

CC(=O)Cc1ccc(OC[Si](C)(C)c2ccc(F)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.47
POLB P06746 1/20 0.44
NR4A2 P43354 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
LMNA P02545 1/20 0.41
PARP10 Q53GL7 1/20 0.40
MAOA P21397 1/20 0.40
GSK3B P49841 1/20 0.40
BACE1 P56817 1/20 0.40
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
GAA P10253 1/20 0.39
KMT2A Q03164 1/20 0.39
TDP1 Q9NUW8 1/20 0.38
FAAH O00519 1/20 0.38
EGFR P00533 1/20 0.38
ERBB2 P04626 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9269526 0.77 POLB (0.56) MAOBPOLBNR4A2SMN1; SMN2MAOA
SCHEMBL7868764 0.76 MAOB (0.43) MAOBNR4A2SMN1; SMN2LMNAPARP10
SCHEMBL7868766 0.76 MAOB (0.43) MAOBNR4A2SMN1; SMN2LMNAPARP10
SCHEMBL48545 0.76 GAA (0.53) POLBSMN1; SMN2LMNARAB9AGAA
SCHEMBL7872444 0.73 MAOB (0.40) MAOBNR4A2SMN1; SMN2LMNAPARP10
SCHEMBL9266213 0.71 TDP1 (0.49) MAOBPOLBSMN1; SMN2LMNARAB9A
SCHEMBL11441230 0.71 MAPT (0.36) POLBLMNAGAAKMT2ATDP1
SCHEMBL2628188 0.70 POLB (0.59) POLBSMN1; SMN2LMNAPARP10NPC1
SCHEMBL2628192 0.69 ALDH1A1 (0.58) POLBSMN1; SMN2LMNAGAA
SCHEMBL2628204 0.69 ALDH1A1 (0.58) POLBSMN1; SMN2LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6313344-B1 PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2001-11-06 US disclosed
EP-0984923-A1 O-BENZYL OXIME ETHERS AND THEIR USE AS PESTICIDES Novartis AG (CH) 2000-03-15 EP disclosed
WO-1998054125-A1 O-BENZYL OXIME ETHERS AND THEIR USE AS PESTICIDES NOVARTIS AG (CH) 1998-12-03 WO disclosed