Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 7/20 | 0.60 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.55 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.55 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734928 | 0.88 | ATM (0.55) | KMT2A | |
| SCHEMBL3498807 | 0.87 | BCHE (0.67) | BCHESPHK2SPHK1GID4MEN1 | |
| Hydrochloric Acid SCHEMBL6433307 | 0.86 | ATM (0.53) | KMT2A | |
| SCHEMBL17923866 | 0.83 | MAOB (0.48) | BCHE | |
| SCHEMBL548 | 0.83 | LTA4H (0.64) | BCHESPHK2SPHK1 | |
| SCHEMBL8760838 | 0.82 | BCHE (0.73) | BCHESPHK2SPHK1GID4 | |
| SCHEMBL832428 | 0.82 | HDAC1 (0.56) | SPHK2MEN1KMT2A | |
| SCHEMBL596575 | 0.82 | HDAC1 (0.67) | BCHEMEN1KMT2A | |
| SCHEMBL6434085 | 0.81 | MEN1 (0.51) | MEN1KMT2A | |
| SCHEMBL8421187 | 0.81 | VSIR (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300501-B1 | Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase | WARNER-LAMBERT COMPANY | 2001-10-09 | — | — | US | disclosed |
| EP-0938494-A1 | INHIBITORS OF PROTEIN FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1997044350-A1 | INHIBITORS OF PROTEIN FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1997-11-27 | — | — | WO | disclosed |