Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12015995 | 0.80 | TSHR (0.48) | KMT2AMEN1TSHRCYP19A1AR | |
| SCHEMBL4271577 | 0.78 | KMT2A (0.58) | KMT2AMEN1TSHRMAPK1HIF1A | |
| SCHEMBL200565 | 0.77 | ALDH1A1 (0.43) | KMT2AMAPK1HIF1A | |
| SCHEMBL27390196 | 0.77 | ALDH1A1 (0.43) | KMT2AMAPK1HIF1A | |
| SCHEMBL3413029 | 0.77 | MEN1 (0.50) | KMT2AMEN1TSHRMAPK1HIF1A | |
| SCHEMBL3995663 | 0.77 | ALDH1A1 (0.43) | KMT2AMAPK1HIF1A | |
| SCHEMBL22097028 | 0.77 | MEN1 (0.56) | KMT2AMEN1TSHRMAPK1HIF1A | |
| SCHEMBL11044891 | 0.75 | KMT2A (0.54) | KMT2AMEN1TSHRMAPK1HIF1A | |
| SCHEMBL27897735 | 0.74 | MEN1 (0.46) | KMT2AMEN1TSHRMAPK1HIF1A | |
| SCHEMBL26402 | 0.74 | MEN1 (1.00) | KMT2AMEN1TSHRMAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300499-B1 | α1-adrenergic receptor antagonists | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-10-09 | — | — | US | disclosed |
| EP-0891344-A1 | ALPHA 1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997037983-A1 | α1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1997-10-16 | — | — | WO | disclosed |