Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | MMP1 | P03956 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL503582 | 0.95 | PDE4B (0.80) | PDE4BCYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL4091233 | 0.90 | PDE4B (0.73) | PDE4BCYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL3383272 | 0.89 | PDE4B (0.82) | PDE4BCYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL16552644 | 0.87 | MMP1 (0.76) | PDE4BCYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL6279662 | 0.86 | MMP1 (0.61) | PDE4BCYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL10884944 | 0.85 | SMN1; SMN2 (0.88) | PDE4BCYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL2413943 | 0.84 | PDE4B (0.93) | PDE4BCYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL99448 | 0.84 | PDE4B (1.00) | PDE4BCYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL4483889 | 0.84 | NPC1 (0.77) | PDE4BCYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL8347297 | 0.83 | PDE4B (0.63) | PDE4BCYP1A2ALDH1A1HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6307089-B2 | Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases | WARNER-LAMBERT COMPANY | 2001-10-23 | — | — | US | disclosed |
| US-6239288-B1 | RHEUMATIC DISEASES | WARNER-LAMBERT COMPANY | 2001-05-29 | — | — | US | disclosed |
| US-20010000513-A1 | Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases | WARNER-LAMBERT COMPANY | 2001-04-26 | — | — | US | disclosed |
| EP-0927156-A1 | BIPHENYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998009940-A1 | BIPHENYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1998-03-12 | — | — | WO | disclosed |
| US-4247466-A | 5-(4'-HYDROXY-4-BIPHENYLYL)-DIHYDRO-2(3H)-FURANEONE; ANTIINFLAMMATORY AGENTS; ANTICOAGULANTS | AMERICAN CYANAMID COMPANY (US) | 1981-01-27 | — | — | US | disclosed |
| US-4219668-A | ANTITHROMBOTIC AND ANTIINFLAMMATORY AGENTS | AMERICAN CYANAMID COMPANY (US) | 1980-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010000513-A1 | Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases | MMP26, MMP1, MMP9 | PDE4B 1128/4885CYP1A2 1694/4885ALDH1A1 573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.