Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.41 |
| ▸ | IKBKB | O14920 | 5/20 | 0.37 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863962 | 0.83 | HTR2A (0.43) | HTR2AHTR2C | |
| SCHEMBL7870962 | 0.77 | REN (0.43) | HTR2AHTR2C | |
| SCHEMBL10202558 | 0.76 | REN (0.47) | — | |
| SCHEMBL7872529 | 0.71 | REN (0.41) | HTR2AIKBKB | |
| SCHEMBL7869218 | 0.68 | REN (0.41) | — | |
| SCHEMBL7876082 | 0.68 | REN (0.42) | — | |
| SCHEMBL19373717 | 0.68 | CYP1A2 (0.41) | HTR2C | |
| SCHEMBL10202444 | 0.67 | REN (0.47) | — | |
| SCHEMBL10202445 | 0.67 | REN (0.60) | — | |
| SCHEMBL7863795 | 0.67 | REN (0.54) | HTR2AIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |