Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DTYMK | P23919 | 1/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27586658 | 0.88 | DTYMK (0.41) | DTYMKSIRT6CASP6TDP1ALDH1A1 | |
| SCHEMBL3513603 | 0.87 | SIRT6 (0.56) | DTYMKSIRT6TDP1ALDH1A1KMT2A | |
| SCHEMBL29706389 | 0.82 | DTYMK (0.62) | DTYMKCASP6TDP1ALDH1A1KMT2A | |
| SCHEMBL60481 | 0.82 | DTYMK (0.62) | DTYMKCASP6TDP1ALDH1A1KMT2A | |
| SCHEMBL23096734 | 0.82 | DTYMK (0.45) | DTYMKCASP6TDP1ALDH1A1MAPT | |
| SCHEMBL7058241 | 0.81 | MAPT (0.47) | DTYMKCASP6TDP1ALDH1A1KMT2A | |
| SCHEMBL8582179 | 0.79 | DTYMK (0.46) | DTYMKCASP6TDP1ALDH1A1KMT2A | |
| SCHEMBL4977817 | 0.77 | ALDH1A1 (0.40) | DTYMKSIRT6ALDH1A1KMT2AMEN1 | |
| SCHEMBL28713313 | 0.77 | DTYMK (0.44) | DTYMKCASP6TDP1ALDH1A1KMT2A | |
| SCHEMBL6551442 | 0.74 | ALDH1A1 (0.61) | TDP1ALDH1A1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6307018-B1 | TWO OLIGOPEPTIDES ARE LIGATED TO FORM A LIGATION PRODUCT HAVING AN AMINOTHIOESTER LINKAGE; IN A SECOND STEP, THE AMINOTHIOESTER LINKAGE REARRANGES TO FORM A PRODUCT HAVING AN N-SUBSTITUTED AMIDE LINKAGE | THE SCRIPPS RESEARCH INSTITUTE | 2001-10-23 | — | — | US | disclosed |