Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7864900 | 1.00 | SLC6A4 (0.66) | SLC6A4KDM4ENPC1LMNAALOX15 | |
| Fumaric Acid SCHEMBL7864904 | 1.00 | SLC6A4 (0.66) | SLC6A4KDM4ENPC1LMNAALOX15 | |
| Maleic Acid SCHEMBL7867976 | 0.93 | SLC6A4 (0.55) | SLC6A4KDM4ENPC1LMNAALOX15 | |
| Fumaric Acid SCHEMBL7867982 | 0.93 | SLC6A4 (0.55) | SLC6A4KDM4ENPC1LMNAALOX15 | |
| Fumaric Acid SCHEMBL7867985 | 0.93 | SLC6A4 (0.55) | SLC6A4KDM4ENPC1LMNAALOX15 | |
| Maleic Acid SCHEMBL7867416 | 0.82 | KDM4E (0.55) | SLC6A4KDM4ENPC1LMNAALOX15 | |
| Fumaric Acid SCHEMBL7867422 | 0.82 | KDM4E (0.55) | SLC6A4KDM4ENPC1LMNAALOX15 | |
| Fumaric Acid SCHEMBL7867426 | 0.82 | KDM4E (0.55) | SLC6A4KDM4ENPC1LMNAALOX15 | |
| Fumaric Acid SCHEMBL7865133 | 0.82 | CYP19A1 (0.45) | SLC6A4KDM4ENPC1LMNAALOX15 | |
| Maleic Acid SCHEMBL7865126 | 0.82 | CYP19A1 (0.45) | SLC6A4KDM4ENPC1LMNAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |