Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.44 |
| ▸ | CDK7 | P50613 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR1F | P30939 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7867999 | 0.94 | DRD2 (0.41) | CYP19A1CHEK1CDK7HTR6DRD2 | |
| Oxalic Acid SCHEMBL7866244 | 0.80 | CCNT1 (0.43) | CHEK1HTR6CCNT1CDK9 | |
| Oxalic Acid SCHEMBL7867409 | 0.80 | KMT2A (0.42) | HTR6HTR1FCCNT1CDK9PARP1 | |
| Oxalic Acid SCHEMBL7867306 | 0.80 | SLC6A4 (0.66) | HTR6DRD2HTR1FSLC6A4 | |
| Oxalic Acid SCHEMBL7867529 | 0.78 | CHRNA7 (0.38) | HTR1FPARP1 | |
| Oxalic Acid SCHEMBL7865005 | 0.78 | KDM4E (0.59) | HTR6DRD2HTR1FSLC6A4 | |
| Oxalic Acid SCHEMBL7865105 | 0.74 | HRH3 (0.44) | CYP19A1CHEK1DRD2DRD4DRD3 | |
| Phosphoric Acid SCHEMBL7859763 | 0.74 | HTR1F (0.42) | HTR6HTR1FCCNT1CDK9 | |
| SCHEMBL7868031 | 0.74 | HTR6 (0.46) | HTR6HTR1FPARP1SLC6A4ALK | |
| Oxalic Acid SCHEMBL7867561 | 0.73 | HTR1D (0.40) | DRD2DRD4HTR1FPARP1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |