Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 4/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | HTR1F | P30939 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7865005 | 0.93 | KDM4E (0.59) | SLC6A4KDM4ELMNAALOX15HTR1A | |
| SCHEMBL6345407 | 0.82 | SLC6A4 (0.69) | SLC6A4HTR1AHTR6 | |
| SCHEMBL7859795 | 0.82 | OPRM1 (0.74) | SLC6A4HTR1AHTR6DRD2HTR2A | |
| SCHEMBL16801569 | 0.81 | SLC6A4 (0.71) | SLC6A4HTR1AHTR6 | |
| SCHEMBL7527363 | 0.80 | SLC6A4 (0.66) | SLC6A4HTR1AHTR6DRD2HTR2A | |
| Oxalic Acid SCHEMBL7865012 | 0.80 | SLC6A4 (0.40) | SLC6A4KDM4ELMNAALOX15HTR1A | |
| Oxalic Acid SCHEMBL7868026 | 0.80 | CYP19A1 (0.44) | SLC6A4HTR6HTR1FDRD2 | |
| SCHEMBL1122074 | 0.80 | SLC6A4 (1.00) | SLC6A4KDM4ELMNAALOX15HTR1A | |
| Oxalic Acid SCHEMBL7867400 | 0.78 | KDM4E (0.55) | SLC6A4KDM4ELMNAALOX15HTR1A | |
| Oxalic Acid SCHEMBL7864882 | 0.78 | KDM4E (0.55) | SLC6A4KDM4ELMNAALOX15HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |