Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL7865021 | 1.00 | KMT2A (0.44) | KMT2AALDH1A1MEN1GAAMAPT | |
| Fumaric Acid SCHEMBL7870869 | 0.81 | ALDH1A1 (0.38) | KMT2AALDH1A1MEN1GAAMAPT | |
| Maleic Acid SCHEMBL7870864 | 0.81 | ALDH1A1 (0.38) | KMT2AALDH1A1MEN1GAAMAPT | |
| Maleic Acid SCHEMBL7868007 | 0.72 | SLC9A1 (0.38) | KMT2AALDH1A1MEN1GAAMAPT | |
| Maleic Acid SCHEMBL7865036 | 0.72 | KDM4E (0.37) | KMT2AALDH1A1MEN1GAAMAPT | |
| Maleic Acid SCHEMBL7867476 | 0.70 | SLC6A4 (0.41) | KMT2AALDH1A1MEN1GAAMAPT | |
| Fumaric Acid SCHEMBL7867483 | 0.70 | SLC6A4 (0.41) | KMT2AALDH1A1MEN1GAAMAPT | |
| Fumaric Acid SCHEMBL8819859 | 0.70 | ALDH1A1 (0.32) | KMT2AALDH1A1MEN1GAAMAPT | |
| Maleic Acid SCHEMBL8819856 | 0.70 | ALDH1A1 (0.32) | KMT2AALDH1A1MEN1GAAMAPT | |
| Fumaric Acid SCHEMBL7865133 | 0.69 | CYP19A1 (0.45) | KMT2AALDH1A1MEN1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |