Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8819859 | 1.00 | ALDH1A1 (0.32) | ALDH1A1LMNAPMP22NPSR1GAA | |
| Maleic Acid SCHEMBL7870864 | 0.86 | ALDH1A1 (0.38) | ALDH1A1LMNAPMP22NPSR1GAA | |
| Fumaric Acid SCHEMBL7870869 | 0.86 | ALDH1A1 (0.38) | ALDH1A1LMNAPMP22NPSR1GAA | |
| Oxalic Acid SCHEMBL7867529 | 0.82 | CHRNA7 (0.38) | ALDH1A1LMNAGAAMAPTKDM4E | |
| SCHEMBL7859754 | 0.70 | DRD2 (0.36) | LMNAKDM4E | |
| Phthalic Acid SCHEMBL7865021 | 0.70 | KMT2A (0.44) | ALDH1A1LMNAGAAMAPTKDM4E | |
| Phthalic Acid SCHEMBL7865014 | 0.70 | KMT2A (0.44) | ALDH1A1LMNAGAAMAPTKDM4E | |
| Maleic Acid SCHEMBL7866335 | 0.70 | HRH4 (0.42) | ALDH1A1LMNAPMP22NPSR1GAA | |
| Fumaric Acid SCHEMBL7866340 | 0.70 | HRH4 (0.42) | ALDH1A1LMNAPMP22NPSR1GAA | |
| Fumaric Acid SCHEMBL7866341 | 0.70 | SLC6A4 (0.39) | ALDH1A1LMNAPMP22NPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997047302-A1 | INHIBITION OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |