Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 5/20 | 0.43 |
| ▸ | HTR6 | P50406 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | QDPR | P09417 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867297 | 0.92 | SIGMAR1 (0.51) | SIGMAR1HTR2CHTR6MAPTHTR1B | |
| SCHEMBL7864911 | 0.82 | SIGMAR1 (0.51) | SIGMAR1HTR2CHTR6MAPTHTR1B | |
| SCHEMBL5756400 | 0.77 | HTR6 (0.44) | SIGMAR1HTR2CHTR6HTR2AHTR7 | |
| Oxalic Acid SCHEMBL7859566 | 0.76 | SLC6A4 (0.42) | HTR6HTR3AQDPR | |
| SCHEMBL4359750 | 0.74 | SIGMAR1 (0.50) | SIGMAR1HTR2CMAPTQDPR | |
| Hydrochloric Acid SCHEMBL8321976 | 0.73 | HTR2C (0.51) | SIGMAR1HTR2CMAPTQDPR | |
| SCHEMBL5756794 | 0.69 | GHSR (0.33) | HTR3A | |
| SCHEMBL5758301 | 0.69 | HTR6 (0.44) | SIGMAR1HTR2CHTR6HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL8709798 | 0.68 | DRD4 (0.53) | SIGMAR1HTR2CHTR6MAPTHTR1B | |
| SCHEMBL5760747 | 0.68 | HTR2A (0.33) | HTR2CHTR2AHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |