Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.63 |
| ▸ | TDO2 | P48775 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.59 |
| ▸ | DRD2 | P14416 | 7/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11223590 | 0.83 | KDM4E (0.73) | HTR1ASLC6A4DRD2HTR2AKDM4E | |
| SCHEMBL7865112 | 0.82 | SLC6A4 (0.81) | HTR1ATDO2SLC6A4KDM4ELMNA | |
| SCHEMBL15064476 | 0.79 | SLC6A4 (0.69) | HTR1ASLC6A4DRD2HTR2ADRD4 | |
| SCHEMBL2935540 | 0.79 | OPRM1 (0.53) | HTR1ASLC6A4DRD2HTR2AKDM4E | |
| SCHEMBL10366941 | 0.79 | OPRM1 (0.71) | HTR1ASLC6A4DRD2HTR7HTR6 | |
| SCHEMBL5473105 | 0.78 | HTR1A (1.00) | HTR1A | |
| SCHEMBL28097370 | 0.78 | TDO2 (0.65) | HTR1ATDO2SLC6A4DRD2ADRA1D | |
| SCHEMBL791945 | 0.77 | DRD2 (0.70) | HTR1ASLC6A4DRD2HTR2ADRD4 | |
| SCHEMBL6811694 | 0.77 | HTR1D (0.67) | HTR1ATDO2SLC6A4DRD2ADRA1D | |
| SCHEMBL6812201 | 0.77 | SLC6A4 (0.58) | HTR1ATDO2SLC6A4DRD2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |