SCHEMBL7865115

SCHEMBL7865115

O=C1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(c2cnc3ccccn23)C1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 4/20 0.38
TSHR P16473 4/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
DDR2 Q16832 1/20 0.36
ALDH1A1 P00352 4/20 0.36
HTT P42858 1/20 0.36
HSD17B10 Q99714 3/20 0.36
CYP2D6 P10635 2/20 0.36
HPGD P15428 1/20 0.36
ALOX15 P16050 1/20 0.36
MAPK1 P28482 1/20 0.36
HIF1A Q16665 1/20 0.36
CYP3A4 P08684 3/20 0.35
HDAC4 P56524 1/20 0.35
MGLL Q99685 1/20 0.35
USP2 O75604 4/20 0.34
CYP2C9 P11712 3/20 0.34
RHOC P08134 2/20 0.34
RHOA P61586 2/20 0.34
CYP2C19 P33261 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7862741 0.78 TACR1 (0.47) TACR1TSHRHSD17B10CYP3A4MGLL
SCHEMBL730772 0.70 TACR1 (0.66) TACR1TSHRCYP2D6CYP3A4USP2
SCHEMBL7684256 0.66 TACR1 (0.55) TACR1TSHRSMN1; SMN2ALDH1A1CYP3A4
SCHEMBL9565788 0.64 RHOC (0.48) TACR1ALDH1A1HSD17B10CYP3A4MGLL
SCHEMBL8923836 0.64 RHOC (0.48) TACR1ALDH1A1HSD17B10CYP3A4MGLL
SCHEMBL8926077 0.64 RHOC (0.48) TACR1ALDH1A1HSD17B10CYP3A4MGLL
SCHEMBL4987212 0.64 TACR1 (0.49) TACR1TSHRSMN1; SMN2ALDH1A1HIF1A
SCHEMBL7688875 0.63 TACR1 (0.49) TACR1SMN1; SMN2HSD17B10CYP2D6CYP3A4
SCHEMBL8924659 0.63 RHOC (0.40) TACR1RHOCRHOA
SCHEMBL12809194 0.63 OPRK1 (0.52) TACR1RHOCRHOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869955-B1 N-ACYL-2-SUBSTITUTED-4-(BENZIMIDAZOLYL- OR IMIDAZOPYRIDINYL-SUBSTITUTED RESIDUES)-PIPERIDINES AS TACHYKININ ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2001-10-24 EP disclosed
US-6110939-A AS A SUBSTANCE P ANTAGONISTS TREATING TACHYKININ-MEDIATED DISEASE, ASTHMA, CENTRAL NERVOUS SYSTEM DISORDER JANSSEN PHARMACEUTICA N.V. (BE) 2000-08-29 US disclosed
EP-0869955-A1 N-ACYL-2-SUBSTITUTED-4-(BENZIMIDAZOLYL- OR IMIDAZOPYRIDINYL-SUBSTITUTED RESIDUES)-PIPERIDINES AS TACHYKININ ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 1998-10-14 EP disclosed
WO-1997024350-A1 N-ACYL-2-SUBSTITUTED-4-(BENZIMIDAZOLYL- OR IMIDAZOPYRIDINYL-SUBSTITUTED RESIDUES)-PIPERIDINES AS TACHYKININ ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 1997-07-10 WO disclosed