Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenoterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 18/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.67 |
| ▸ | MC4R | P32245 | 1/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.67 |
| ▸ | MC3R | P41968 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenoterol SCHEMBL9791330 | 0.90 | ADRB2 (0.82) | ADRB2CYP3A4MAPK1NPSR1TSHR | |
| Fenoterol SCHEMBL3793462 | 0.87 | ADRB2 (0.77) | ADRB2CYP3A4MAPK1NPSR1TSHR | |
| SCHEMBL10872409 | 0.87 | ADRB2 (0.68) | ADRB2CYP3A4MAPK1NPSR1TSHR | |
| SCHEMBL10872412 | 0.87 | ADRB2 (0.68) | ADRB2CYP3A4MAPK1NPSR1TSHR | |
| Ractopamine SCHEMBL6754854 | 0.85 | ADRB2 (0.64) | ADRB2CYP3A4MAPK1NPSR1TSHR | |
| Fenoterol SCHEMBL249376 | 0.82 | ADRB2 (1.00) | ADRB2CYP3A4MAPK1NPSR1TSHR | |
| Fenoterol SCHEMBL9971023 | 0.82 | ADRB2 (1.00) | ADRB2CYP3A4MAPK1NPSR1TSHR | |
| Fenoterol SCHEMBL5009 | 0.82 | ADRB2 (1.00) | ADRB2CYP3A4MAPK1NPSR1TSHR | |
| Fenoterol SCHEMBL9971031 | 0.82 | ADRB2 (1.00) | ADRB2CYP3A4MAPK1NPSR1TSHR | |
| Fenoterol SCHEMBL9971022 | 0.82 | ADRB2 (1.00) | ADRB2CYP3A4MAPK1NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119334-A1 | TWO CHAMBER CARTRIDGE FOR ATOMIZERS | Boehringer Ingelheim Pharma KG (DE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000023037-A1 | TWO CHAMBER CARTRIDGE FOR ATOMIZERS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-04-27 | — | — | WO | disclosed |
| EP-0946146-A2 | NEW AQUEOUS MEDICAMENT PREPARATIONS FOR THE PRODUCTION OF PROPELLENT GAS-FREE AEROSOLS | Boehringer Ingelheim Pharma KG (DE) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027959-A2 | NEW AQUEOUS MEDICAMENT PREPARATIONS FOR THE PRODUCTION OF PROPELLENT GAS-FREE AEROSOLS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-07-02 | — | — | WO | disclosed |
| EP-0835098-A1 | NEW, STABLE MEDICINAL COMPOSITIONS FOR GENERATING PROPELLANT-FREE AEROSOLS | BOEHRINGER INGELHEIM KG (DE) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997001329-A1 | NEW, STABLE MEDICINAL COMPOSITIONS FOR GENERATING PROPELLANT-FREE AEROSOLS | BOEHRINGER INGELHEIM KG (DE) | 1997-01-16 | — | — | WO | disclosed |
| US-5266589-A | Dihydroxyphenylethanolamine compound | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1993-11-30 | — | — | US | disclosed |