Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 17/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14459065 | 1.00 | HSD11B1 (0.56) | HSD11B1POLBMEN1KMT2AUSP2 | |
| SCHEMBL28786482 | 0.82 | HSD11B1 (0.54) | HSD11B1POLBMEN1KMT2A | |
| SCHEMBL28786484 | 0.82 | HSD11B1 (0.54) | HSD11B1POLBMEN1KMT2A | |
| SCHEMBL26519 | 0.81 | CYP1A2 (0.42) | HSD11B1POLBUSP2ALDH1A1LMNA | |
| SCHEMBL5398452 | 0.79 | HSD11B1 (0.37) | HSD11B1ALDH1A1 | |
| SCHEMBL27727 | 0.78 | CYP1A2 (0.44) | HSD11B1POLBUSP2ALDH1A1LMNA | |
| SCHEMBL7861905 | 0.78 | ALDH1A1 (0.44) | HSD11B1POLBUSP2ALDH1A1LMNA | |
| SCHEMBL21169316 | 0.77 | POLB (0.39) | HSD11B1POLBMEN1KMT2AUSP2 | |
| SCHEMBL19982306 | 0.77 | POLB (0.39) | HSD11B1POLBMEN1KMT2AUSP2 | |
| SCHEMBL21707491 | 0.74 | HSD11B1 (0.37) | HSD11B1POLBMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888285-B1 | NOVEL BRIDGED CYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS | WARNER LAMBERT CO (US) | 2001-12-12 | — | — | EP | disclosed |
| US-6020370-A | ANTIEPILEPIC AGENT, BRAIN DISORDERS, NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS, ANALGESICS | WARNER-LAMBERT COMPANY (US) | 2000-02-01 | — | — | US | disclosed |
| EP-0888285-A1 | NOVEL BRIDGED CYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997033859-A1 | NOVEL BRIDGED CYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1997-09-18 | — | — | WO | disclosed |