Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 2/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | ATP4A | P20648 | 1/20 | 0.40 |
| ▸ | ATP4B | P51164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1298270 | 0.84 | RAB9A (0.53) | MAPTITKAPPKDM4EALDH1A1 | |
| SCHEMBL17433387 | 0.82 | CYP19A1 (0.58) | MAPTAPPKDM4EALDH1A1LMNA | |
| SCHEMBL4472858 | 0.79 | APP (0.49) | APPCLK1DYRK1ACYP1A2CYP2A6 | |
| SCHEMBL22955636 | 0.75 | NPC1 (0.43) | MAPTITKHTR2AHTR2CAPP | |
| SCHEMBL8309554 | 0.75 | MAPT (1.00) | MAPTFLT3ITKCYP1A1ATP4A | |
| SCHEMBL4887738 | 0.74 | KDM4E (0.64) | MAPTFLT3ITKCYP1A1KDM4E | |
| SCHEMBL17433476 | 0.73 | ESR1 (0.47) | ITKAPPCYP2A6NPC1RAB9A | |
| Methane SCHEMBL28844909 | 0.72 | KDM4E (0.62) | MAPTFLT3ITKCYP1A1KDM4E | |
| SCHEMBL10831846 | 0.72 | CYP1A1 (0.61) | MAPTFLT3ITKCYP1A1KDM4E | |
| SCHEMBL28073052 | 0.72 | APP (0.68) | MAPTAPPALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1097460-C | Cytotoxic amino sugars and related sugar derivatives of indolopyrrolocarbazoles | BRISTOL MYERS SQUIBB CO (US) | 2003-01-01 | — | — | CN | disclosed |
| EP-0971717-B1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL MYERS SQUIBB CO (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0971717-A4 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL MYERS SQUIBB CO (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0971717-A1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | Bristol-Myers Squibb Company (US) | 2000-01-19 | — | — | EP | disclosed |
| CN-1228704-A | Cytotoxic amino sugars and related sugar derivatives of indolopyrrolocarbazoles | BRISTOL MYERS SQUIBB CO (US) | 1999-09-15 | — | — | CN | disclosed |
| WO-1998007433-A1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-02-26 | — | — | WO | disclosed |