Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 3/20 | 0.56 |
| ▸ | DPP4 | P27487 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29350459 | 0.85 | TSHR (0.50) | PNMTDPP4ALDH1A1TSHRTAAR1 | |
| SCHEMBL150237 | 0.85 | TSHR (0.50) | PNMTDPP4ALDH1A1TSHRTAAR1 | |
| SCHEMBL29405036 | 0.85 | PNMT (0.63) | PNMTDPP4TAAR1LOXL2CYP2A6 | |
| SCHEMBL15247 | 0.85 | PNMT (0.63) | PNMTDPP4TAAR1LOXL2CYP2A6 | |
| SCHEMBL28683639 | 0.82 | PNMT (0.62) | PNMTDPP4TAAR1LOXL2CYP2A6 | |
| Water SCHEMBL7618285 | 0.82 | PNMT (0.60) | PNMTDPP4TAAR1LOXL2CYP2A6 | |
| Water SCHEMBL6142580 | 0.82 | PNMT (0.60) | PNMTDPP4TAAR1LOXL2CYP2A6 | |
| Hydrochloric Acid SCHEMBL2522138 | 0.82 | PNMT (0.60) | PNMTDPP4TAAR1LOXL2CYP2A6 | |
| Hydrochloric Acid SCHEMBL31276815 | 0.82 | PNMT (0.60) | PNMTDPP4TAAR1LOXL2CYP2A6 | |
| Benzene SCHEMBL734438 | 0.82 | DPP4 (0.62) | PNMTDPP4TAAR1LOXL2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3475282-B1 | [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES WITH AFFINITY FOR THE TYPE-2 CANNABINOID RECEPTOR | HOFFMANN LA ROCHE (CH) | 2023-08-09 | — | — | EP | disclosed |
| EP-4108665-A1 | [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES WITH AFFINITY FOR THE TYPE-2 CANNABINOID RECEPTOR | F. Hoffmann-La Roche AG (CH) | 2022-12-28 | — | — | EP | disclosed |
| US-10457685-B2 | [1,2,3]triazolo[4,5-D]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor | HOFFMANN-LA ROCHE INC. (US) | 2019-10-29 | — | — | US | disclosed |
| US-20190127384-A1 | [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES WITH AFFINITY FOR THE TYPE-2 CANNABINOID RECEPTOR | HOFFMANN-LA ROCHE INC. (US) | 2019-05-02 | — | — | US | disclosed |
| WO-2007091176-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | disclosed |
| US-6320058-B2 | SUBJECTING SOLUTION OF PHTHALONITRILE IN TETRAHYDROFURAN, MIXTURE OF TETRAHYDROFURAN AND WATER, OR DIMETHOXYETHANE TO HYDROGEN PRESSURE OF 100 TO 180 BARS, AT TEMPERATURE OF 30 TO 100 DEGREES C., AND IN PRESENCE OF 5% PLATINUM ON CARBON | ADIR ET COMPAGNIE (FR) | 2001-11-20 | — | — | US | disclosed |
| US-20010023294-A1 | New process for the preparation of isoindoline | KISSEI PHARMACEUTICAL COMPANY LTD (JP) | 2001-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190127384-A1 | [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES WITH AFFINITY FOR THE TYPE-2 CANNABINOID RECEPTOR | CNR2, CNR1, P2RY2 | PNMT 603/4885DPP4 3203/4885ALDH1A1 2101/4885 |
| US-20010023294-A1 | New process for the preparation of isoindoline | HPD, GABRB2, NISCH | PNMT 1830/4885DPP4 623/4885ALDH1A1 420/4885 |
| US-10457685-B2 | [1,2,3]triazolo[4,5-D]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor | CNR2, CNR1, P2RY2 | PNMT 603/4885DPP4 3203/4885ALDH1A1 2101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.