Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 5/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.64 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.58 |
| ▸ | GABRR2 | P28476 | 3/20 | 0.58 |
| ▸ | BLM | P54132 | 3/20 | 0.58 |
| ▸ | GABRR3 | A8MPY1 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.44 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 3/20 | 0.39 |
| ▸ | GABRD | O14764 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL18065037 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3KMT2A | |
| Fumaric Acid SCHEMBL2840791 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3KMT2A | |
| Maleic Acid SCHEMBL786851 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3KMT2A | |
| Fumaric Acid SCHEMBL18065038 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3KMT2A | |
| Maleic Acid SCHEMBL28320762 | 0.91 | TSHR (0.53) | TSHRTP53EGLN1EGLN3KMT2A | |
| Ethylenediamine SCHEMBL28100956 | 0.88 | TSHR (0.50) | TSHRTP53EGLN1EGLN3KMT2A | |
| Fumaric Acid SCHEMBL1835362 | 0.87 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Maleic Acid SCHEMBL30550381 | 0.87 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Maleic Acid SCHEMBL28650191 | 0.87 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Fumaric Acid SCHEMBL8771350 | 0.87 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 173 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111763573-A | Alkaline glass substrate cleaning fluid composition | 昆山欣谷微电子材料有限公司 | 2020-10-13 | — | — | CN | claimed |
| EP-1940228-B1 | BAIT COMPOSITIONS COMPRISING AT LEAST ONE SPINOSYN AND ONE MOLLUSCICIDE | NEUDORFF W GMBH KG (DE) | 2015-07-29 | — | — | EP | claimed |
| US-20130206181-A1 | AUTOMATIC DISHWASHING COMPOSITION | INNOSPEC LIMITED (GB) | 2013-08-15 | — | — | US | claimed |
| EP-2619301-A1 | AUTOMATIC DISHWASHING COMPOSITION | Innospec Limited (GB) | 2013-07-31 | — | — | EP | claimed |
| WO-2012038755-A1 | AUTOMATIC DISHWASHING COMPOSITION | INNOSPEC LIMITED (GB) | 2012-03-29 | — | — | WO | claimed |
| US-7964205-B2 | Insecticide and molluscicide composition and methods | W. NEUDORFF GMBH KG (DE) | 2011-06-21 | — | — | US | claimed |
| EP-1940228-A2 | BAIT COMPOSITIONS COMPRISING AT LEAST ONE SPINOSYN AND ONE MOLLUSCICIDE | W. Neudorff GmbH KG (DE) | 2008-07-09 | — | — | EP | claimed |
| US-20070148203-A1 | Insecticide and molluscicide composition and methods | W. NEUDORFF GMBH KG (DE) | 2007-06-28 | — | — | US | claimed |
| WO-2007031565-A2 | BAIT COMPOSITIONS COMPRISING AT LEAST ONE SPINOSYN AND ONE MOLLUSCICIDE | W. NEUDORFF GMBH KG (DE) | 2007-03-22 | — | — | WO | claimed |
| US-20030118625-A1 | Ingestible molluscicide | W. NEUDORFF GMBH KG (DE) | 2003-06-26 | — | — | US | claimed |
| EP-1312260-A1 | Ingestible molluscicide | W. Neudorff GmbH KG (DE) | 2003-05-21 | — | — | EP | claimed |
| EP-4396318-A1 | MACHINE DISHWASH DETERGENT | Unilever IP Holdings B.V. (NL) | 2024-07-10 | — | — | EP | disclosed |
| EP-4396319-A1 | MACHINE DISHWASH DETERGENT | Unilever IP Holdings B.V. (NL) | 2024-07-10 | — | — | EP | disclosed |
| EP-4396317-A1 | MACHINE DISHWASH DETERGENT | Unilever IP Holdings B.V. (NL) | 2024-07-10 | — | — | EP | disclosed |
| US-20240218295-A1 | MACHINE DISHWASH DETERGENT | CONOPCO INC., D/B/A UNILEVER (US) | 2024-07-04 | — | — | US | disclosed |
| US-6852329-B2 | Transition metal compound and a complexing agent, and/or the complex of a transition metal compound and a complexing agents | W. NEUDORFF GMBH KG (DE) | 2005-02-08 | — | — | US | disclosed |
| US-20030118625-A1 | Ingestible molluscicide | W. NEUDORFF GMBH KG (DE) | 2003-06-26 | — | — | US | disclosed |
| US-20030118625-A1 | Ingestible molluscicide | W. NEUDORFF GMBH KG (DE) | 2003-06-26 | — | — | US | disclosed |
| EP-1312260-A1 | Ingestible molluscicide | W. Neudorff GmbH KG (DE) | 2003-05-21 | — | — | EP | disclosed |
| EP-1312260-A1 | Ingestible molluscicide | W. Neudorff GmbH KG (DE) | 2003-05-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030118625-A1 | Ingestible molluscicide | DDT, IDUA, NRDC | KMT2A 2787/4885MEN1 537/4885TSHR 2221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.