Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.56 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.52 |
| ▸ | GABRR2 | P28476 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 3/20 | 0.52 |
| ▸ | GABRR3 | A8MPY1 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.39 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL5874279 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Fumaric Acid SCHEMBL3965703 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Maleic Acid SCHEMBL30550381 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Maleic Acid SCHEMBL3118035 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Fumaric Acid SCHEMBL27921137 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Fumaric Acid SCHEMBL1835362 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Maleic Acid SCHEMBL28650191 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Maleic Acid SCHEMBL18065037 | 0.87 | TSHR (0.64) | TSHRTP53EGLN1EGLN3KMT2A | |
| Fumaric Acid SCHEMBL2840791 | 0.87 | TSHR (0.64) | TSHRTP53EGLN1EGLN3KMT2A | |
| Maleic Acid SCHEMBL786851 | 0.87 | TSHR (0.64) | TSHRTP53EGLN1EGLN3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10256449-B2 | Porous membrane separator for secondary battery, method for producing the same, and secondary battery | ZEON CORPORATION (JP) | 2019-04-09 | — | — | US | disclosed |
| EP-2903055-B1 | POROUS MEMBRANE SEPARATOR FOR SECONDARY BATTERIES, METHOD FOR PRODUCING SAME, AND SECONDARY BATTERY | ZEON CORP (JP) | 2017-08-30 | — | — | EP | disclosed |
| EP-2755256-B1 | SLURRY FOR SECONDARY BATTERIES | ZEON CORP (JP) | 2016-10-26 | — | — | EP | disclosed |
| US-20150270523-A1 | POROUS MEMBRANE SEPARATOR FOR SECONDARY BATTERY, METHOD FOR PRODUCING THE SAME, AND SECONDARY BATTERY | ZEON CORPORATION (JP) | 2015-09-24 | — | — | US | disclosed |
| EP-2903055-A1 | POROUS MEMBRANE SEPARATOR FOR SECONDARY BATTERIES, METHOD FOR PRODUCING SAME, AND SECONDARY BATTERY | Zeon Corporation (JP) | 2015-08-05 | — | — | EP | disclosed |
| US-20140212728-A1 | SLURRY FOR SECONDARY BATTERIES | ZEON CORPORATION (JP) | 2014-07-31 | — | — | US | disclosed |
| EP-0798320-A2 | Ternary copolymer | NOF CORPORATION (JP) | 1997-10-01 | — | — | EP | disclosed |