Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | MEN1 | O00255 | 7/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | DDX3X | O00571 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.56 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.56 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6725074 | 0.86 | KMT2A (0.72) | SMN1; SMN2KMT2AMAPTMEN1POLB | |
| SCHEMBL12523964 | 0.85 | SMN1; SMN2 (0.76) | SMN1; SMN2KMT2AMAPTMEN1POLB | |
| SCHEMBL1248559 | 0.85 | SMN1; SMN2 (1.00) | SMN1; SMN2KMT2AMAPTMEN1POLB | |
| SCHEMBL1592991 | 0.83 | KMT2A (0.68) | SMN1; SMN2KMT2AMAPTMEN1POLB | |
| SCHEMBL3126901 | 0.83 | SMN1; SMN2 (0.73) | SMN1; SMN2KMT2AMAPTMEN1POLB | |
| SCHEMBL4185556 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2KMT2AMAPTMEN1POLB | |
| Hydrochloric Acid SCHEMBL1592637 | 0.82 | KMT2A (0.66) | SMN1; SMN2KMT2AMAPTMEN1POLB | |
| SCHEMBL1047211 | 0.81 | MEN1 (1.00) | SMN1; SMN2KMT2AMAPTMEN1POLB | |
| Nitric Acid SCHEMBL2283510 | 0.81 | KMT2A (0.64) | SMN1; SMN2KMT2AMAPTMEN1POLB | |
| SCHEMBL30856804 | 0.80 | SMN1; SMN2 (0.72) | SMN1; SMN2KMT2AMAPTMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37438-E1 | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. | 2001-11-06 | — | — | US | disclosed |
| US-5866612-A | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. (US) | 1999-02-02 | — | — | US | disclosed |
| EP-0799191-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019440-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-06-27 | — | — | WO | disclosed |