Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.37 |
| ▸ | MPL | P40238 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2399327 | 0.93 | PDE2A (0.43) | PDE2AADRB2SLC6A4RPS6KB1MPL | |
| SCHEMBL296445 | 0.93 | PDE2A (0.43) | PDE2AADRB2SLC6A4RPS6KB1MPL | |
| SCHEMBL4228847 | 0.93 | PDE2A (0.43) | PDE2AADRB2SLC6A4RPS6KB1MPL | |
| SCHEMBL5019023 | 0.93 | PDE2A (0.43) | PDE2AADRB2SLC6A4RPS6KB1MPL | |
| Hydrochloric Acid SCHEMBL26615659 | 0.91 | PDE2A (0.42) | PDE2AADRB2SLC6A4RPS6KB1MPL | |
| Hydrochloric Acid SCHEMBL3701319 | 0.91 | PDE2A (0.42) | PDE2AADRB2SLC6A4RPS6KB1MPL | |
| SCHEMBL7782591 | 0.91 | ADRB2 (0.42) | PDE2AADRB2SLC6A4HTR2AHTR2C | |
| SCHEMBL7865721 | 0.84 | TAAR1 (0.45) | PDE2ARPS6KB1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21153574 | 0.83 | KIF11 (0.45) | PDE2AADRB2MPL | |
| Ammonia Solution, Strong SCHEMBL7569458 | 0.82 | IDO1 (0.40) | ADRB2SLC6A4CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140913-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000034269-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |