Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM4B | O94953 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511392 | 0.82 | SYK (0.39) | METAP2METAP1KDM4AKDM4BKDM5C | |
| SCHEMBL6516547 | 0.74 | DHODH (0.40) | METAP2METAP1KDM4AKDM4BKDM5C | |
| SCHEMBL7863726 | 0.74 | ESR1 (0.41) | METAP2METAP1KDM4AKDM4BKDM5C | |
| SCHEMBL9911398 | 0.73 | METAP1 (0.47) | METAP2METAP1BDKRB2NPC1RAB9A | |
| SCHEMBL7855710 | 0.73 | HCRTR1 (0.43) | KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL5184165 | 0.73 | MAPT (0.47) | SMN1; SMN2KDM4ENPC1RAB9AMAPT | |
| SCHEMBL6513353 | 0.71 | KDM4A (0.42) | METAP1KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL18003950 | 0.70 | ALDH1A1 (0.46) | METAP2METAP1KDM4AKDM4BKDM5C | |
| SCHEMBL4515967 | 0.69 | CYP19A1 (0.47) | METAP2METAP1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL7367797 | 0.68 | CSNK2A1 (0.64) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086097-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER INC. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064415-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-12-16 | — | — | WO | disclosed |