Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7865580 | 0.90 | CYP1A2 (0.46) | LTA4HCYP1A2MGAMGAASI | |
| SCHEMBL7858923 | 0.88 | TSHR (0.46) | LTA4HCYP1A2TSHRALDH1A1NR1I2 | |
| SCHEMBL25785111 | 0.86 | MEN1 (0.46) | MEN1KMT2ALTA4HCYP1A2MGAM | |
| SCHEMBL4788929 | 0.84 | MEN1 (0.60) | MEN1KMT2ALTA4HCYP1A2MGAM | |
| SCHEMBL11701536 | 0.83 | CA12 (0.48) | LTA4HCYP1A2MGAMGAASI | |
| SCHEMBL11668776 | 0.79 | MEN1 (0.54) | MEN1KMT2ALTA4HCYP1A2MGAM | |
| SCHEMBL27794859 | 0.78 | CYP1A2 (0.44) | CYP1A2MGAMGAASIMGAM2 | |
| SCHEMBL20937014 | 0.77 | LTA4H (0.54) | MEN1KMT2ALTA4HCYP1A2MGAM | |
| SCHEMBL9830045 | 0.77 | MEN1 (0.52) | MEN1KMT2ALTA4HCYP1A2MGAM | |
| SCHEMBL8632462 | 0.77 | CYP1A2 (0.55) | MEN1KMT2ALTA4HCYP1A2MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1085667-C | Substituted tetracyclic azepine derivatives having affinity for 5-HT2 receptors | JANSSEN PHARMACEUTICA NV (BE) | 2002-05-29 | — | — | CN | disclosed |
| EP-0789701-B1 | SUBSTITUTED TETRACYCLIC AZEPINE DERIVATIVES WHICH HAVE AFFINITY FOR 5-HT2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2001-02-07 | — | — | EP | disclosed |
| CN-1162313-A | Substituted tetracyclic azepine derivatives having affinity for 5-HT2 receptors | JANSSEN PHARMACEUTICA NV (BE) | 1997-10-15 | — | — | CN | disclosed |
| EP-0789701-A1 | SUBSTITUTED TETRACYCLIC AZEPINE DERIVATIVES WHICH HAVE AFFINITY FOR 5-HT2 RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-08-20 | — | — | EP | disclosed |
| US-5552399-A | TREATMENT OR PREVENTION OF CENTRAL NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS, GASTROINTESTINAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-03 | — | — | US | disclosed |
| WO-1996014320-A1 | SUBSTITUTED TETRACYCLIC AZEPINE DERIVATIVES WHICH HAVE AFFINITY FOR 5-HT2 RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-17 | — | — | WO | disclosed |