Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | TERT | O14746 | 5/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5970252 | 0.89 | LTA4H (0.48) | LTA4HTERTHPGDSCHEK1MMP2 | |
| SCHEMBL5970300 | 0.86 | SIRT5 (0.52) | HPGDSSIRT5 | |
| SCHEMBL5970942 | 0.86 | SIRT5 (0.52) | HPGDSSIRT5 | |
| SCHEMBL5970333 | 0.84 | HDAC4 (0.45) | HPGDSMMP2SIRT5 | |
| SCHEMBL5970093 | 0.84 | HPGDS (0.55) | HPGDS | |
| SCHEMBL5970269 | 0.84 | HPGDS (0.43) | HPGDSSIRT5 | |
| SCHEMBL5970396 | 0.82 | HDAC4 (0.51) | TERTFNTAFNTBLMNA | |
| SCHEMBL5970983 | 0.81 | SIRT5 (0.55) | HPGDSSIRT5 | |
| SCHEMBL5970139 | 0.81 | SIRT5 (0.55) | HPGDSSIRT5 | |
| SCHEMBL5970372 | 0.78 | SIRT5 (0.54) | SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080070-A2 | ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY | ABBOTT LABORATORIES (US) | 2001-03-07 | — | — | EP | claimed |
| WO-1999061406-A2 | ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY | ABBOTT LABORATORIES (US) | 1999-12-02 | — | — | WO | claimed |
| EP-1080070-A2 | ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY | ABBOTT LABORATORIES (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061406-A2 | ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY | ABBOTT LABORATORIES (US) | 1999-12-02 | — | — | WO | disclosed |