Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 4/20 | 0.35 |
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.34 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | SCN1A | P35498 | 2/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | APEX1 | P27695 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9788455 | 0.76 | SCN1A (0.41) | SCN1ASCN2ASCN3ACHRM5CHRM1 | |
| SCHEMBL15239912 | 0.76 | SCN1A (0.37) | SCN1ASCN2ASCN3ACHRM5CHRM1 | |
| SCHEMBL15265688 | 0.72 | PRKD3 (0.39) | SCN1ASCN2ASCN3ASMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL22409396 | 0.70 | SCN1A (0.43) | SCN1ASCN2ASCN3ACHRM5CHRM1 | |
| Iodide SCHEMBL30960405 | 0.70 | SCN1A (0.42) | SCN1ASCN2ASCN3ACHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL29067668 | 0.68 | CHRM1 (0.45) | SCN1ASCN2ASCN3ACHRM5CHRM1 | |
| SCHEMBL28202670 | 0.67 | — | — | |
| SCHEMBL5944501 | 0.67 | SCN1A (0.45) | SCN1ASCN2ASCN3ACHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL15993829 | 0.67 | CHRM1 (0.52) | SCN1ASCN2ASCN3ACHRM5CHRM1 | |
| SCHEMBL9751161 | 0.67 | MEN1 (0.36) | SMN1; SMN2LMNAAPEX1TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730636-B1 | MICROEMULSION ALL PURPOSE LIQUID CLEANING COMPOSITIONS | COLGATE PALMOLIVE CO (US) | 2001-04-25 | — | — | EP | disclosed |