Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7704838 | 0.85 | ALDH1A1 (0.67) | KMT2APAX8HTTNPSR1ALDH1A1 | |
| SCHEMBL7868867 | 0.83 | ALDH1A1 (0.65) | KMT2APAX8HTTNPSR1ALDH1A1 | |
| SCHEMBL7862237 | 0.81 | KMT2A (0.57) | KMT2APAX8HTTNPSR1ALDH1A1 | |
| SCHEMBL1951415 | 0.80 | KMT2A (0.76) | KMT2APAX8ALDH1A1RECQLHSD11B1 | |
| SCHEMBL780498 | 0.79 | NPC1 (0.63) | KMT2APAX8NPC1RAB9AL3MBTL1 | |
| SCHEMBL6180942 | 0.79 | NPC1 (0.63) | KMT2APAX8NPC1RAB9AL3MBTL1 | |
| SCHEMBL28629860 | 0.78 | NPC1 (0.71) | KMT2ANPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL7866928 | 0.78 | NPC1 (0.51) | KMT2APAX8NPC1RAB9AL3MBTL1 | |
| SCHEMBL5218244 | 0.78 | NPC1 (0.81) | KMT2ANPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL6168486 | 0.78 | CA1 (0.62) | KMT2ANPC1RAB9AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300514-B1 | INHIBITING MATRIX METALLOPROTEINASES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | claimed |
| EP-0994104-A1 | ARYL (SULFIDE, SULFOXIDE AND SULFONE) DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-04-19 | — | — | EP | claimed |
| US-6300514-B1 | INHIBITING MATRIX METALLOPROTEINASES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | disclosed |
| EP-0994104-A1 | ARYL (SULFIDE, SULFOXIDE AND SULFONE) DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-04-19 | — | — | EP | disclosed |