Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7704838 | 0.89 | ALDH1A1 (0.67) | KMT2APAX8ALDH1A1HTTNPSR1 | |
| SCHEMBL7868867 | 0.87 | ALDH1A1 (0.65) | KMT2APAX8ALDH1A1HTTNPSR1 | |
| SCHEMBL7866978 | 0.81 | KMT2A (0.60) | KMT2APAX8ALDH1A1HTTNPSR1 | |
| SCHEMBL28579307 | 0.81 | KMT2A (0.59) | KMT2APAX8ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL7862238 | 0.80 | ALDH1A1 (0.56) | KMT2APAX8ALDH1A1HTTNPSR1 | |
| SCHEMBL7072972 | 0.80 | KMT2A (0.56) | KMT2APAX8ALDH1A1HTTKDM4E | |
| SCHEMBL6470799 | 0.79 | KDM4E (0.66) | KMT2APAX8ALDH1A1HTTNPSR1 | |
| SCHEMBL19066564 | 0.79 | ALDH1A1 (0.69) | KMT2APAX8ALDH1A1HTTNPSR1 | |
| SCHEMBL12106076 | 0.79 | HTT (0.62) | KMT2APAX8ALDH1A1HTTNPSR1 | |
| SCHEMBL7869978 | 0.79 | HTT (0.62) | KMT2APAX8ALDH1A1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300514-B1 | INHIBITING MATRIX METALLOPROTEINASES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | claimed |
| EP-0994104-A1 | ARYL (SULFIDE, SULFOXIDE AND SULFONE) DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-04-19 | — | — | EP | claimed |
| US-6300514-B1 | INHIBITING MATRIX METALLOPROTEINASES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | disclosed |
| EP-0994104-A1 | ARYL (SULFIDE, SULFOXIDE AND SULFONE) DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-04-19 | — | — | EP | disclosed |