Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoromethanesulfonic Acid SCHEMBL7870840 | 0.93 | SLC6A4 (0.50) | DRD2SLC6A4HTR2AHTR7HTR1A | |
| SCHEMBL8820411 | 0.90 | SLC6A4 (0.60) | DRD2SLC6A4ADRA1DHTR2AHTR7 | |
| Trifluoromethanesulfonic Acid SCHEMBL7867430 | 0.82 | DRD2 (0.46) | DRD2SLC6A4HTR2AHTR7HTR6 | |
| SCHEMBL8819815 | 0.82 | SLC6A4 (0.56) | DRD2SLC6A4ADRA1DHTR2AHTR7 | |
| Trifluoromethanesulfonic Acid SCHEMBL7865117 | 0.81 | DRD2 (0.39) | DRD2SLC6A4HTR7ADRA1B | |
| Trifluoromethanesulfonic Acid SCHEMBL7870898 | 0.80 | HTR1F (0.43) | DRD2SLC6A4ADRA1DKCNH2HTR2A | |
| Trifluoromethanesulfonic Acid SCHEMBL7866323 | 0.80 | DRD2 (0.46) | DRD2SLC6A4HTR2AHTR7HTR1A | |
| Trifluoromethanesulfonic Acid SCHEMBL7859713 | 0.79 | KDR (0.41) | — | |
| Trifluoromethanesulfonic Acid SCHEMBL7859761 | 0.78 | HTR1A (0.51) | DRD2SLC6A4HTR2AHTR7HTR1A | |
| SCHEMBL9031074 | 0.77 | HTR1A (0.47) | DRD2SLC6A4HTR2AHTR7SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |