Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 8/20 | 0.42 |
| ▸ | CDK9 | P50750 | 8/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7864922 | 0.83 | DRD4 (0.40) | CCNT1CDK9DRD4DRD2DRD3 | |
| Oxalic Acid SCHEMBL8113849 | 0.80 | OPRM1 (0.38) | CHEK1DRD2KDM4EALDH1A1PARP1 | |
| SCHEMBL15558979 | 0.79 | CUL4A (0.40) | CHEK1TLR9KDM4EALDH1A1MAPT | |
| Oxalic Acid SCHEMBL7865105 | 0.77 | HRH3 (0.44) | DRD4CHEK1TLR9DRD2DRD3 | |
| Oxalic Acid SCHEMBL7867436 | 0.77 | HRH3 (0.44) | CCNT1CDK9DRD4CHEK1DRD2 | |
| SCHEMBL6027967 | 0.77 | SMN1; SMN2 (0.38) | CCNT1CDK9TLR9KDM4EHTT | |
| Oxalic Acid SCHEMBL7870865 | 0.77 | SLC6A4 (0.47) | DRD4DRD2DRD3KDM4EALDH1A1 | |
| Maleic Acid SCHEMBL8820580 | 0.76 | KDM4E (0.32) | CCNT1CDK9KDM4EPARP1PARP2 | |
| SCHEMBL7100358 | 0.76 | PARP1 (0.45) | CCNT1CDK9KMT2APARP1PARP2 | |
| Phosphoric Acid SCHEMBL7867331 | 0.75 | PARP1 (0.36) | CCNT1CDK9TLR9KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |