Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.47 |
| ▸ | HTR1F | P30939 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | HTR7 | P34969 | 5/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7867275 | 0.83 | SLC6A4 (0.47) | SLC6A4DRD4CCR2KDM4EBRD4 | |
| Oxalic Acid SCHEMBL7867934 | 0.79 | DRD2 (0.43) | SLC6A4DRD4ALDH1A1NOS3NOS1 | |
| SCHEMBL8876262 | 0.78 | SLC6A4 (0.57) | SLC6A4CCR2 | |
| Oxalic Acid SCHEMBL7867572 | 0.77 | SLC6A4 (0.50) | SLC6A4CCR2KDM4EBRD4ALDH1A1 | |
| Oxalic Acid SCHEMBL7867428 | 0.77 | CCNT1 (0.42) | DRD4KDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL14163184 | 0.75 | DRD4 (0.54) | SLC6A4DRD4NOS3NOS1DRD2 | |
| Oxalic Acid SCHEMBL7866371 | 0.74 | DRD2 (0.43) | SLC6A4DRD4ALDH1A1NOS3NOS1 | |
| Oxalic Acid SCHEMBL7864882 | 0.74 | KDM4E (0.55) | SLC6A4HTR1FKDM4EPOLBHTR2A | |
| SCHEMBL9033610 | 0.74 | MEN1 (0.45) | SLC6A4KDM4EALDH1A1POLBHTR2A | |
| SCHEMBL8879489 | 0.74 | HTR2C (0.54) | SLC6A4NOS3NOS1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |