Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30930834 | 0.98 | MEN1 (0.40) | MEN1KMT2ATDP1LTA4HTSHR | |
| SCHEMBL31592759 | 0.98 | MEN1 (0.40) | MEN1KMT2ATDP1LTA4HTSHR | |
| SCHEMBL8392272 | 0.95 | MAPK1 (0.36) | TDP1LTA4HTSHRMAPK1LMNA | |
| SCHEMBL30930835 | 0.89 | MGLL (0.40) | TSHRALDH1A1 | |
| SCHEMBL30930837 | 0.89 | MGLL (0.40) | TSHRALDH1A1 | |
| SCHEMBL27568866 | 0.81 | — | — | |
| SCHEMBL27906013 | 0.78 | TAAR1 (0.36) | LTA4HTP53MAPK1PLA2G2A | |
| SCHEMBL31264315 | 0.69 | GPR84 (0.46) | PTPN1GPR84 | |
| SCHEMBL9501121 | 0.69 | LMNA (0.36) | TSHRTP53LMNAGPR84CHRM2 | |
| SCHEMBL27325161 | 0.69 | GPR84 (0.46) | PTPN1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017687-A4 | PROCESS OF MAKING 3-ARYLOXY, 4-ARYL FURAN-2-ONES USEFUL AS INHIBITORS OF COX-2 | MERCK & CO INC (US) | 2001-10-31 | — | — | EP | disclosed |
| US-6140515-A | Process of making 3-aryloxy, 4-aryl furan-2-ones useful as inhibitors of COX-2 | MERCK & CO., INC. (US) | 2000-10-31 | — | — | US | disclosed |
| CN-1271352-A | Process for preparing 3-aryloxy, 4-arylfuran-2-ones useful as cyclooxygenase-2 inhibitors | MERCK & CO INC (US) | 2000-10-25 | — | — | CN | disclosed |
| EP-1017687-A1 | PROCESS OF MAKING 3-ARYLOXY, 4-ARYL FURAN-2-ONES USEFUL AS INHIBITORS OF COX-2 | Merck & Co., Inc. (US) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015513-A1 | PROCESS OF MAKING 3-ARYLOXY, 4-ARYL FURAN-2-ONES USEFUL AS INHIBITORS OF COX-2 | MERCK & CO., INC. (US) | 1999-04-01 | — | — | WO | disclosed |