Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874244 | 0.92 | P4HTM (0.48) | P4HTMOPRM1OPRD1OPRK1EPHX2 | |
| SCHEMBL7874552 | 0.89 | P4HTM (0.46) | P4HTMPTPN1OPRM1OPRD1OPRK1 | |
| SCHEMBL7862825 | 0.87 | P4HTM (0.43) | P4HTMOPRM1OPRD1OPRK1EPHX2 | |
| SCHEMBL7862735 | 0.86 | P4HTM (0.56) | P4HTM | |
| SCHEMBL7871645 | 0.83 | P4HTM (0.58) | P4HTMPTPN1OPRM1OPRD1OPRK1 | |
| SCHEMBL9018056 | 0.82 | P4HTM (0.63) | P4HTMPTPN1OPRM1OPRD1OPRK1 | |
| SCHEMBL7870554 | 0.82 | NPC1 (0.49) | P4HTMNPC1RAB9ASMN1; SMN2CA1 | |
| SCHEMBL7862679 | 0.81 | P4HTM (0.56) | P4HTMPTPN1OPRM1OPRD1OPRK1 | |
| SCHEMBL7869436 | 0.80 | NPC1 (0.44) | P4HTMOPRM1OPRD1OPRK1EPHX2 | |
| SCHEMBL7871594 | 0.80 | MMP8 (0.46) | P4HTMOPRM1OPRD1OPRK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |