Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874244 | 0.93 | P4HTM (0.48) | P4HTMGABRA5OPRM1OPRD1OPRK1 | |
| SCHEMBL7867686 | 0.89 | P4HTM (0.58) | P4HTMGABRA5OPRM1OPRD1OPRK1 | |
| SCHEMBL7862825 | 0.86 | P4HTM (0.43) | P4HTMGABRA5OPRM1OPRD1OPRK1 | |
| SCHEMBL7867903 | 0.83 | P4HTM (0.44) | P4HTMGABRA5OPRM1OPRD1OPRK1 | |
| SCHEMBL7871605 | 0.83 | HSP90AA1 (0.44) | P4HTMNPC1RAB9ASMN1; SMN2HDAC1 | |
| SCHEMBL9018358 | 0.83 | GABRA5 (0.49) | P4HTMGABRA5OPRM1OPRD1OPRK1 | |
| SCHEMBL7871588 | 0.82 | P4HTM (0.51) | P4HTMGABRA5OPRM1OPRD1OPRK1 | |
| SCHEMBL7869436 | 0.82 | NPC1 (0.44) | P4HTMOPRM1OPRD1OPRK1NPC1 | |
| SCHEMBL7869446 | 0.82 | GABRA5 (0.45) | P4HTMGABRA5OPRM1OPRD1OPRK1 | |
| SCHEMBL7871594 | 0.82 | MMP8 (0.46) | P4HTMOPRM1OPRD1OPRK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |