Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | GRN | P28799 | 2/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7871752 | 0.90 | CXCR1 (0.39) | P4HTMGABRA5CXCR1CXCR2EPHX2 | |
| SCHEMBL7874244 | 0.89 | P4HTM (0.48) | P4HTMGABRA5CXCR2MMP1MMP13 | |
| SCHEMBL7867686 | 0.87 | P4HTM (0.58) | P4HTMGABRA5CXCR2MMP1MMP2 | |
| SCHEMBL7874552 | 0.86 | P4HTM (0.46) | P4HTMGABRA5OPRM1OPRD1EPHX2 | |
| SCHEMBL7869443 | 0.84 | P4HTM (0.43) | P4HTMGABRA5CXCR1CXCR2MEN1 | |
| SCHEMBL9018289 | 0.83 | P4HTM (0.46) | P4HTMGABRA5CXCR1CXCR2GRN | |
| SCHEMBL7862735 | 0.83 | P4HTM (0.56) | P4HTMMCL1MEN1KMT2A | |
| SCHEMBL7862809 | 0.83 | GABRA5 (0.43) | P4HTMGABRA5MEN1KMT2AOPRM1 | |
| SCHEMBL7867675 | 0.82 | NPC1 (0.49) | P4HTMMCL1MEN1KMT2A | |
| SCHEMBL7871594 | 0.82 | MMP8 (0.46) | P4HTMMMP13MEN1KMT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |