Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 7/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7867764 | 0.74 | HTR6 (0.55) | HTR6HDAC4DRD2HTR1AHTR2A | |
| SCHEMBL7867384 | 0.73 | HTR6 (0.59) | HTR6HDAC4DRD2HTR1AHTR2A | |
| SCHEMBL4030523 | 0.66 | HDAC4 (0.61) | HDAC4DRD2HTR1AHTR2AHTT | |
| SCHEMBL2395932 | 0.65 | DRD4 (0.67) | HDAC4DRD2HTR1AHTR2AHTT | |
| SCHEMBL10287534 | 0.63 | SIGMAR1 (0.71) | HTR6HDAC4DRD2HTR1AHTR2A | |
| SCHEMBL11784970 | 0.63 | HTR6 (0.65) | HTR6DRD2HTR1AHTR2AHTT | |
| SCHEMBL6585625 | 0.63 | DRD4 (0.63) | HDAC4DRD2HTR1AHTR2AHTT | |
| SCHEMBL2396123 | 0.62 | HDAC4 (0.58) | HDAC4DRD2HTR1AHTR2AHTT | |
| SCHEMBL29188191 | 0.62 | DRD4 (0.67) | HDAC4DRD2HTR1AHTR2AHTT | |
| SCHEMBL2394181 | 0.62 | NAMPT (0.58) | HDAC4NAMPTKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1997047302-A1 | INHIBITION OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |