Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869173 | 0.92 | RAB9A (0.44) | HTTRAB9AALDH1A1LMNAMAPK1 | |
| SCHEMBL7871636 | 0.92 | RAB9A (0.46) | HTTRAB9AALDH1A1EPHX2POLB | |
| SCHEMBL7871628 | 0.91 | HTT (0.53) | HTTRAB9AALDH1A1GAAHSD17B10 | |
| SCHEMBL7871663 | 0.91 | EPHX2 (0.49) | ALDH1A1EPHX2LMNAL3MBTL1P4HTM | |
| SCHEMBL7871660 | 0.90 | SMN1; SMN2 (0.42) | HTTRAB9APOLBLMNAP4HTM | |
| SCHEMBL7862676 | 0.89 | RAB9A (0.46) | RAB9AALDH1A1POLBHDAC8HDAC6 | |
| SCHEMBL7862681 | 0.89 | HSD17B10 (0.43) | HTTRAB9AHSD17B10LMNAP4HTM | |
| SCHEMBL7862689 | 0.89 | RAB9A (0.43) | HTTRAB9AALDH1A1LMNAP4HTM | |
| SCHEMBL9018296 | 0.89 | HTT (0.55) | HTTRAB9AALDH1A1GAAHSD17B10 | |
| SCHEMBL7871609 | 0.87 | P4HTM (0.55) | MAPK1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |