Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018432 | 0.93 | HTT (0.52) | HTTALDH1A1GAAHSD17B10HDAC8 | |
| SCHEMBL9018282 | 0.92 | RAB9A (0.53) | HTTALDH1A1HDAC8HDAC6HDAC2 | |
| SCHEMBL9018122 | 0.91 | HTT (0.50) | HTTALDH1A1GAAHSD17B10HDAC8 | |
| SCHEMBL9018089 | 0.90 | HTT (0.51) | HTTALDH1A1GAAHSD17B10HDAC8 | |
| SCHEMBL9018085 | 0.90 | RAB9A (0.47) | HTTALDH1A1HDAC8HDAC6POLB | |
| SCHEMBL9018007 | 0.89 | ALDH1A1 (0.46) | HTTALDH1A1HDAC8HDAC6EPHX2 | |
| SCHEMBL7867889 | 0.89 | HTT (0.51) | HTTALDH1A1GAAHSD17B10HDAC8 | |
| SCHEMBL9018408 | 0.89 | SMN1; SMN2 (0.46) | HTTALDH1A1LMNAP4HTM | |
| SCHEMBL9018274 | 0.87 | RAB9A (0.48) | ALDH1A1HDAC8HDAC6POLBHDAC2 | |
| SCHEMBL9018118 | 0.87 | RAB9A (0.44) | HTTALDH1A1RAB9ALMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |