Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862846 | 0.91 | LMNA (0.47) | LMNATSHRSMN1; SMN2CYP3A4HTR1A | |
| SCHEMBL7870547 | 0.90 | HTT (0.48) | HTTKMT2AALDH1A1GAA | |
| SCHEMBL7867700 | 0.89 | LMNA (0.45) | LMNATSHRSMN1; SMN2CYP3A4HTR1A | |
| SCHEMBL7870524 | 0.86 | SMN1; SMN2 (0.46) | LMNATSHRSMN1; SMN2MAPTHTT | |
| SCHEMBL8868071 | 0.85 | LMNA (0.55) | LMNATSHRSMN1; SMN2CYP3A4HTR1A | |
| SCHEMBL7862898 | 0.85 | LMNA (0.47) | LMNATSHRSMN1; SMN2CYP3A4HTR1A | |
| SCHEMBL7870549 | 0.85 | MAPT (0.47) | LMNATSHRSMN1; SMN2CYP3A4HTR1A | |
| SCHEMBL9018193 | 0.85 | LMNA (0.53) | LMNATSHRSMN1; SMN2BLMHTT | |
| SCHEMBL7870571 | 0.84 | EPHX2 (0.45) | LMNATSHRSMN1; SMN2CYP3A4HTR1A | |
| SCHEMBL7871681 | 0.84 | EGFR (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |