Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ENPP3 | O14638 | 5/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869495 | 0.92 | LMNA (0.45) | SMN1; SMN2TSHRMAPK1LMNAALDH1A1 | |
| SCHEMBL7870549 | 0.89 | MAPT (0.47) | SMN1; SMN2TSHRMAPK1LMNAALDH1A1 | |
| SCHEMBL8869050 | 0.87 | SMN1; SMN2 (0.49) | SMN1; SMN2TSHRMAPK1LMNAALDH1A1 | |
| SCHEMBL7867896 | 0.86 | LMNA (0.49) | SMN1; SMN2TSHRLMNAALDH1A1KMT2A | |
| SCHEMBL9018265 | 0.85 | LMNA (0.50) | SMN1; SMN2TSHRMAPK1LMNAALDH1A1 | |
| SCHEMBL7874570 | 0.85 | EGFR (0.44) | SMN1; SMN2ALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL7869457 | 0.83 | P4HTM (0.47) | SMN1; SMN2MAPK1LMNAKMT2AMEN1 | |
| SCHEMBL7874562 | 0.83 | EGFR (0.43) | SMN1; SMN2ALDH1A1KMT2AMEN1CXCR1 | |
| SCHEMBL7867890 | 0.82 | POLB (0.40) | SMN1; SMN2TSHRLMNAALDH1A1KMT2A | |
| SCHEMBL7869400 | 0.81 | CA12 (0.42) | SMN1; SMN2ALDH1A1KMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |