Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.45 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869470 | 0.97 | PTGDR (0.44) | PTGDR2PTGDRKMT2AL3MBTL1HPGD | |
| SCHEMBL7874624 | 0.95 | PTGDR (0.42) | PTGDR2PTGDRKMT2AL3MBTL1HPGD | |
| SCHEMBL7874566 | 0.94 | MAPT (0.43) | PTGDR2PTGDRKMT2AL3MBTL1HPGD | |
| SCHEMBL7874281 | 0.92 | SMN1; SMN2 (0.43) | PTGDR2PTGDRKMT2AHPGDRAB9A | |
| SCHEMBL9018121 | 0.91 | PTGDR (0.44) | PTGDR2PTGDRKMT2AL3MBTL1HPGD | |
| SCHEMBL8869043 | 0.89 | HPGD (0.44) | PTGDR2PTGDRKMT2AL3MBTL1HPGD | |
| SCHEMBL9018514 | 0.88 | PTGDR (0.42) | PTGDR2PTGDRKMT2AL3MBTL1HPGD | |
| SCHEMBL7874619 | 0.86 | HPGD (0.47) | KMT2AL3MBTL1HPGDRAB9ANPC1 | |
| SCHEMBL8869162 | 0.85 | HPGD (0.47) | PTGDR2PTGDRKMT2AL3MBTL1HPGD | |
| SCHEMBL7862781 | 0.85 | POLB (0.43) | KMT2AL3MBTL1HPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |