Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 10/20 | 0.41 |
| ▸ | RAB9A | P51151 | 9/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867672 | 0.93 | SMN1; SMN2 (0.44) | SMN1; SMN2CA1CA2CA9NPC1 | |
| SCHEMBL7867910 | 0.92 | PTGDR2 (0.45) | SMN1; SMN2NPC1RAB9APTGDRPTGDR2 | |
| SCHEMBL7867692 | 0.91 | SMN1; SMN2 (0.44) | SMN1; SMN2CA1CA2CA9NPC1 | |
| SCHEMBL7862675 | 0.91 | SMN1; SMN2 (0.45) | SMN1; SMN2CA1CA2CA9NPC1 | |
| SCHEMBL8868727 | 0.90 | SMN1; SMN2 (0.46) | SMN1; SMN2CA1CA2CA9NPC1 | |
| SCHEMBL7869470 | 0.89 | PTGDR (0.44) | SMN1; SMN2NPC1RAB9APTGDRPTGDR2 | |
| SCHEMBL7874624 | 0.87 | PTGDR (0.42) | SMN1; SMN2NPC1RAB9APOLBPTGDR | |
| SCHEMBL7862722 | 0.87 | NPC1 (0.51) | SMN1; SMN2NPC1RAB9APOLBCASP3 | |
| SCHEMBL7874566 | 0.87 | MAPT (0.43) | SMN1; SMN2NPC1RAB9APTGDRPTGDR2 | |
| SCHEMBL7874495 | 0.86 | ALDH1A1 (0.46) | SMN1; SMN2CA1CA2CA9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |