Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | KDM4A | O75164 | 5/20 | 0.46 |
| ▸ | KDM4B | O94953 | 5/20 | 0.46 |
| ▸ | KDM5C | P41229 | 5/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.46 |
| ▸ | DRD4 | P21917 | 4/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.45 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9048518 | 0.93 | OPRM1 (0.58) | OPRM1OPRK1OPRL1KDM4AKDM4B | |
| Oxalic Acid SCHEMBL9049148 | 0.89 | OPRM1 (0.55) | OPRM1OPRK1OPRL1KDM4AKDM4B | |
| Oxalic Acid SCHEMBL7859768 | 0.89 | OPRM1 (0.48) | OPRM1OPRK1OPRL1KDM4AKDM4B | |
| Oxalic Acid SCHEMBL9045773 | 0.86 | OPRM1 (0.51) | OPRM1OPRK1OPRL1KDM4AKDM4B | |
| Oxalic Acid SCHEMBL9048940 | 0.86 | OPRM1 (0.51) | OPRM1OPRK1OPRL1KDM4AKDM4B | |
| Oxalic Acid SCHEMBL9044366 | 0.86 | OPRM1 (0.51) | OPRM1OPRK1OPRL1KDM4AKDM4B | |
| Oxalic Acid SCHEMBL9046671 | 0.86 | OPRM1 (0.51) | OPRM1OPRK1OPRL1KDM4AKDM4B | |
| Oxalic Acid SCHEMBL7864877 | 0.85 | OPRM1 (0.44) | OPRM1OPRK1OPRL1DRD2AVPR1A | |
| Oxalic Acid SCHEMBL9046888 | 0.85 | CCR2 (0.44) | OPRM1OPRK1OPRL1KDM4AKDM4B | |
| Oxalic Acid SCHEMBL9046848 | 0.85 | HTR1A (0.51) | OPRM1OPRK1OPRL1KDM4AKDM4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1997047302-A1 | INHIBITION OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |